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. 2016 Dec 15;2016(12):CD002830. doi: 10.1002/14651858.CD002830.pub3

Comparison 2. Droperidol versus haloperidol.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Tranquillisation or asleep: 1. tranquillised/sleep within 120 minutes 1 228 Risk Ratio (M‐H, Fixed, 95% CI) 1.01 [0.93, 1.09]
2 Tranquillisation or asleep: 2. time to tranquillisation/sleep     Other data No numeric data
3 Global state: use of additional medication 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
3.1 Midazolam administered initially 1 228 Risk Ratio (M‐H, Random, 95% CI) 3.26 [0.69, 15.37]
3.2 By 30 minutes 1 27 Risk Ratio (M‐H, Random, 95% CI) 0.45 [0.20, 1.01]
3.3 By 60 minutes 2 255 Risk Ratio (M‐H, Random, 95% CI) 0.37 [0.16, 0.90]
3.4 By 90 minutes 1 27 Risk Ratio (M‐H, Random, 95% CI) 0.47 [0.02, 10.63]
4 Global state: no overall improvement ‐ by 30 days 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.67 [0.29, 1.52]
5 Adverse effects 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 Cardiovascular ‐ hypotension 1 228 Risk Ratio (M‐H, Fixed, 95% CI) 2.80 [0.30, 26.49]
5.2 Cardiovascular ‐ hypotension/desaturation 1 228 Risk Ratio (M‐H, Fixed, 95% CI) 2.80 [0.12, 67.98]
5.3 Central nervous system ‐ extrapyramidal adverse effects 1 228 Risk Ratio (M‐H, Fixed, 95% CI) 2.80 [0.12, 67.98]
5.4 Central nervous system ‐ oversedation 1 228 Risk Ratio (M‐H, Fixed, 95% CI) 2.80 [0.12, 67.98]
5.5 Staff injuries 1 228 Risk Ratio (M‐H, Fixed, 95% CI) 0.56 [0.14, 2.29]
6 Mental state: Average score by 13 days (Scale for Quantification of Psychotic Symptom Severity, high = poor) 1 40 Mean Difference (IV, Fixed, 95% CI) 0.11 [‐0.07, 0.29]