Supplementary Table 5.
Significantly enriched pathway terms of three significant modules in protein–protein interaction networks.
| Term | Database | ID | P-value | Count |
|---|---|---|---|---|
| Module 1 | ||||
| Collagen biosynthesis and modifying enzymes | Reactome | R-HSA-1650814 | 2.76E-44 | 16 |
| Collagen formation | Reactome | R-HSA-1474290 | 1.42E-42 | 16 |
| Collagen degradation | Reactome | R-HSA-1442490 | 4.31E-37 | 14 |
| Extracellular matrix organization | Reactome | R-HSA-1474244 | 1.01E-34 | 16 |
| Assembly of collagen fibrils | Reactome | R-HSA-2022090 | 1.42E-34 | 13 |
| Module 2 | ||||
| Platelet degranulation | Reactome | R-HSA-114608 | 9.13E-15 | 6 |
| Response to elevated platelet cytosolic Ca2+ | Reactome | R-HSA-76005 | 1.14E-14 | 6 |
| Hemostasis | Reactome | R-HSA-109582 | 1.98E-13 | 7 |
| Platelet activation, signaling and aggregation | Reactome | R-HSA-76002 | 8.57E-13 | 6 |
| Extracellular matrix organization | Reactome | R-HSA-1474244 | 4.51E-10 | 5 |
| Module 3 | ||||
| O-linked glycosylation of mucins | Reactome | R-HSA-913709 | 6.69E-12 | 5 |
| Chemical carcinogenesis | KEGG PATHWAY | hsa05204 | 2.04E-11 | 5 |
| O-linked glycosylation | Reactome | R-HSA-5173105 | 8.07E-11 | 5 |
| Metabolic pathways | KEGG PATHWAY | hsa01100 | 1.42E-10 | 8 |
| Biological oxidations | Reactome | R-HSA-211859 | 1.49E-09 | 5 |