Table 2.
Hub genes in the protein–protein interaction networks identified by cytoHubba.
| Gene symbol | Official full name | Degree | Expression in GC |
|---|---|---|---|
| COL1A1 | Collagen type I alpha 1 chain | 32 | Up-regulation |
| COL3A1 | Collagen type III alpha 1 chain | 32 | Up-regulation |
| COL1A2 | Collagen type I alpha 2 chain | 31 | Up-regulation |
| COL5A2 | Collagen type V alpha 2 chain | 23 | Up-regulation |
| FN1 | Fibronectin 1 | 23 | Up-regulation |
| THBS1 | Thrombospondin 1 | 22 | Up-regulation |
| COL5A1 | Collagen type V alpha 1 chain | 22 | Up-regulation |
| SPARC | Secreted protein acidic and cysteine rich | 22 | Up-regulation |
| COL18A1 | Collagen type XVIII alpha 1 chain | 21 | Up-regulation |
| COL11A1 | Collagen type XI alpha 1 chain | 20 | Up-regulation |
GC – gastric cancer.