1.9. Analysis.

Comparison 1 Antivirals versus placebo/no treatment, Outcome 9 Development of complications of infectious mononucleosis.

Development of complications of infectious mononucleosis
Study
Andersson 1986	ACV group: 'the most severely ill patient also had a mild infection with herpes zoster virus in the L2 region at admission. He had a tracheotomy because of an airway obstruction; this was followed by a transient, bilateral hypoglossal nerve palsy." Placebo group: "One patient was operated on on the 12th day after admission because of abdominal pain. Surgical diagnosis was pseudoappendicitis. One patient suffered from hepatitis that persisted for seven months with mild icterus. No other etiologic agent could be demonstrated."
Andersson 1987	There were ‘three patients with over‐whelming clinical symptoms causing airway obstruction and/or disseminated intravascular coagulopathy". These 3 patients were treated with a combination of IV antiviral and steroids
Balfour 2007a	"A 24‐year‐old subject developed acute pancreatitis on the 10th study day and was hospitalized for 2 days for medical management. She was taken off clinical trial material and not re‐challenged.The blind was not broken. She is entirely well. When the code was broken, we learned that she was in the valomaciclovir arm. Thus, this SAE is possibly drug‐related, although I considered it more likely caused by EBV infection because pancreatitis has been reported to be a complication of infectious mononucleosis."
Balfour 2007b	Not mentioned
Pagano 1983	Not mentioned
Simon 2003	Not mentioned
van der Horst 1991	Not mentioned