Date	Event	Description
29 April 2014	New citation required but conclusions have not changed	The previous co‐author, Dr Anton Tan, has stepped down and a new co‐author, Nikki Jahnke, has joined the review team. No new references have been added to this review, hence the conclusions remain the same.
29 April 2014	New search has been performed	A search of the Cystic Fibrosis and Genetic Disorders Cystic Fibrosis Trials Register identified seven references to six potentially eligible studies all of which were excluded from the review (Beringer 2012; Blumer 2005; Hatziagorou 2013; Keel 2011; McCabe 2013; Semykin 2010).
17 October 2012	Amended	Contact details updated.
3 November 2011	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register identified 15 new references potentially eligible for inclusion in this review. However, none of the references were suitable for inclusion in the review.
15 September 2009	New search has been performed	A search of the Group's Cystic Fibrosis Register identified no new references which were potentially eligible for inclusion in this review.
11 November 2008	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register identified no new references eligible for inclusion in this review.
11 November 2008	Amended	Converted to new review format.
20 February 2008	Amended	The 'Plain Language Summary' has been updated in line with latest guidance from The Cochrane Collaboration.
20 February 2008	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register identified no new references eligible for inclusion in this review.
21 February 2007	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register identified no new references eligible for inclusion in this review.
15 February 2006	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register identified no new references.
9 February 2005	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register identified no new references. One previously included trial has now been excluded from the review (Padoan 1987). In this trial a total of 40 courses of treatment took place (20 in each intervention group). The trial was cross‐over in design, however, re‐randomisation took place between courses of treatment, resulting in some participants possibly receiving two or more courses of the same treatment, or a mixture of different treatments. Since the number of participants receiving each treatment was unclear, results could not be included in the analysis of this review and therefore the trial was excluded.
9 February 2005	New citation required and conclusions have changed	Substantive amendment
13 November 2002	New search has been performed	Excluded Studies: One additional study has been added ‐ Krause 1979 . An additional reference to the Nelson 1985 study has also been included.