Comparison 2. Oral doxycycline versus intravenous ceftriaxone for Lyme neuroborreliosis (acute and chronic).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mean reduction in clinical score (4 months)	1	102	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐1.20, 1.40]
2 Resolution of symptoms	1	102	Risk Ratio (M‐H, Fixed, 95% CI)	1.44 [0.89, 2.35]
3 All adverse events	1	113	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.51, 1.23]
4 Adverse events leading to discontinuation	1	118	Risk Ratio (M‐H, Fixed, 95% CI)	0.14 [0.01, 2.71]
5 Serious adverse events	1	113	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.04, 3.05]