NCT02553473.

Trial name or title	Six versus two weeks treatment with doxycycline in Lyme neuroborreliosis
Methods	Multicenter, non‐inferiority, randomized, penta‐blind (participant, caregiver, investigator, outcomes assessor), placebo‐controlled study
Participants	250 adults (18 years and older) with neuroborreliosis (Borrelia burgdorferi) from Norwegian hospitals Inclusion criteria: neurological symptoms suggestive of Lyme neuroborreliosis without other obvious causes, one or both of a) cerebrospinal fluid pleocytosis (> 5 leukocytes/mm3), b) intrathecal B. burgdorferi antibody production
Interventions	Doxycycline 200 mg once daily for 6 weeks versus doxycycline 200 mg once daily for 2 weeks + placebo for 4 weeks
Outcomes	Primary: composite clinical score at 6 months after the end of treatment Secondary: Fatigue Severity Scale (FSS), Patient Health Questionnaire (PHQ‐15), 36‐Item Short‐Form Health Survey (SF‐36), and blood and cerebrospinal fluid findings at inclusion and after 6 and 12 months Safety
Starting date	October 2015
Contact information	Sorlandet Hospital
Notes	Estimated completion 2020