| Methods |
RCT, DB single oral and multiple oral dose, 3 parallel groups
Medication administered when baseline pain reached a moderate to severe intensity
Pain assessed at 0, 15, 30, 45, 60, 90 mins then hourly up to 12 h |
| Participants |
Impacted third molar extraction
Mean age 22 years
N = 174
M = 75, F = 99 |
| Interventions |
Celecoxib 200 mg, n = 74
Ibuprofen liquigel 400 mg, n = 74
Placebo, n = 26 |
| Outcomes |
PI: 4‐point scale
PR: 5‐point scale
PGE: std 5‐point scale (patients reporting "very good" or "excellent")
Time to use of rescue medication
Number of participants using rescue medication
Number of participants reporting any adverse event and serious adverse events
Number of participants withdrawing due to adverse event |
| Notes |
Oxford Quality Score: R2, DB2, W1
Participants asked to refrain from rescue medication for 1 h |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"computer‐generated allocation schedule" |
| Allocation concealment (selection bias) |
Unclear risk |
Not described |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Double‐dummy method. "The appearance, presentation and labelling of the placebo formulations were identical to those of the corresponding active drugs" |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Participants accounted for; analysis appropriate for relevant time interval |
| Size |
Unclear risk |
Small treatment group size (74 active, 26 placebo participants) |
