| Methods |
RCT, DB single oral dose, 5 parallel groups
Medication administered when baseline pain reached a moderate to severe intensity
Pain assessed at 0, 15, 30, 45, 60, and 90 mins, then at 2, 3, 4, 5, 6, 7, 8, and 12 h |
| Participants |
Impacted third molar extraction
Mean age 22 years
N = 482
M = 124, F = 358 |
| Interventions |
Celecoxib 400 mg, n = 151
Celecoxib 200 mg, n = 90
Rofecoxib 50 mg, n = 150
Ibuprofen 400 mg, n = 45
Placebo, n = 45 |
| Outcomes |
PI: std 4‐point scale
PR: std 5‐point scale
PGE: std 5‐point scale
Time to use of rescue medication
Number of participants using rescue medication |
| Notes |
Oxford Quality Score: R2, DB2, W1
Participants asked to refrain from rescue medication for 1.5 h |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"computer‐generated allocation schedule" |
| Allocation concealment (selection bias) |
Low risk |
Participants allocated to next randomisation number (lowest for moderate pain, highest for severe pain) |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Double‐dummy method. Each active treatment had matching placebo tablets or capsules |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Participants accounted for; analysis appropriate for relevant time interval |
| Size |
Unclear risk |
Small treatment group size (90 to 151 coxib, 45 to 50 ibuprofen, and placebo participants) |
