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. 2016 Dec 21;2016(12):CD004371. doi: 10.1002/14651858.CD004371.pub4

1. Matrix of comparisons in included studies.

  Intervention
Comparator intervention   1) simplification of drug regimen 2) patient education and information 3) intensified patient care1 4) complex behavioural approaches2 5) decision support systems3 6) administrative improvements4 7) pharmacy‐led intervention
1) simplification of drug regimen N/A            
2) patient education and information   N/A          
3) intensified patient care1     N/A        
4) complex behavioural approaches2       N/A Kooy 2013;
Pladevall 2014 		   
5) decision support systems3         N/A    
6) administrative improvements4           N/A  
7) pharmacy‐led intervention             N/A
8) usual care/placebo Brown 1997;
Castellano 2014;
Patel 2015;
PILL 2011;
Selak 2014;
Sweeney 1991;
Thom 2013 		Gujral 2014;
Park 2013;
Poston 1998;
Powell 1995;
Willich 2009 		Aslani 2010; Derose 2012;
Eussen 2010; Fang 2015; Faulkner 2000;
Goswami 2013;
Guthrie 2001Ho 2014;
Kardas 2013; Ma 2010;
Márquez 2004;
Márquez 2007;
Nieuwkerk 2012;
Schectman 1994;
Vrijens 2006;
Wald 2014 		Márquez 1998   Choudhry 2011; Tamblyn 2009 Fischer 2014; Vollmer 2014

1 Intensified patient care includes increased follow‐up, sending out reminders, etc.
2 Complex behavioural approaches include increasing motivation by arranging group sessions, giving out rewards, etc.
3 Decision support systems include computer‐based information systems aimed at support of decision‐making.
4 Administrative improvements include audit, documentation, computers.

N/A: not applicable