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. 2017 Jan 10;2017(1):CD010971. doi: 10.1002/14651858.CD010971.pub2

Weydert 2006.

Methods RCT with active control
Follow‐up: postintervention (4 weeks) and 2 months' follow‐up
Participants Location: USA
Setting: recruited from GP referrals and paediatric gastroenterology clinics
Sample size: 27 children (16 intervention, 11 control)
Sex: 7 boys, 15 girls
Dropouts/withdrawals: 2 intervention, 3 control (all prior to starting allocation)
Diagnosis: RAP diagnosed using Apley criteria (Apley 1958)
Mean age: intervention: 11.1 years (SD not reported; range not reported); control: 11.0 (SD not reported; range not reported) years. Data not reported for groups overall.
Interventions Intervention: guided imagery and progressive muscle relaxation, for child only (individual), 60 minutes/week x 4, with daily homework
Control: breathing technique training, 60 minutes/week x 4, to control for therapist time and attention, with daily homework
Outcomes
  1. Number of days with pain (diary)

  2. Pain intensity (FACES Pain Scale; Bieri 1990)

  3. Missed days of school (diary)

  4. Depression (Child Depression Inventory; Kovacs 1992)

  5. Anxiety (Multidimensional Anxiety Scale for Children; Reynolds 1985)

  6. Treatment success (4 or fewer days of pain with no missed activities during each month)

Notes Study dates: 2000 to June 2002
Funding: National Center for Complementary and Alternative Medicine grant
Declarations of interest: Authors reported no conflicts of interest.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Comment: blocks of 4 (tokens in a hat)
Allocation concealment (selection bias) Low risk Comment: separate group responsible for randomisation
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: personnel blinded to group (both called "relaxation techniques"), but unsure of the degree of participant blinding (depends on how treatments were explained)
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: researcher recording outcomes was blind to treatment allocation. Although participants self reported outcome, attempts were made to blind participants to their treatment allocation.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: accounts for participants
Selective reporting (reporting bias) Low risk Comment: all outcomes reported
Other bias Unclear risk Comment: sample size calculations not reported, but otherwise well reported

FAP: functional abdominal pain
 FGID: functional gastrointestinal disorders
 GP: general practitioner
 IBS: irritable bowel syndrome
 KINDL‐R: KINDer Lebensqualitätsfragebogen
 P‐PDI: Paediatric Pain Disability Index
 PedsQL: Pediatric Quality of Life Inventory
 RAP: recurrent abdominal pain
 RCT: randomised controlled trial
 SD: standard deviation