Diener 1989

Methods	D: parallel C: unclear B: double WD: 8/58 J: 1‐1‐0 DU: 2m/7m/1‐2m
Participants	N: 58/50 D: 4 migraine with, 54 without aura C: Ad Hoc F: 81 A: mean age 43 years DU: 1‐55 years S: unclear, Germany
Interventions	P: 80‐160 mg C1: Metoprolol 100‐200 mg C2: Nifedipine 20‐40 mg
Outcomes	R: 6/19 vs. 12/22 vs. 1/17 (according to time series analysis) F: greater reduction in metoprolol group, but relevant baseline differences AU: no significant differences HI: not measured AEs: more circulatory disturbances with propanolol, more fatigue with metoprolol Dropouts‐AEs: not reported V: (‐) vs. C1, (+) vs. C2
Notes	Rigorous study Dropout rates not fully clear
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear