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. 2017 Feb 17;2017(2):CD003225. doi: 10.1002/14651858.CD003225.pub3
Methods D: parallel C: unclear B: double WD: 18/94 J: 1‐1‐0 DU: 1m/4m/‐
Participants N: 94/76 (89 in safety analysis) D: 37 migraine with and 57 without aura C: World Federation of Neurology Research Group F: 90% A: mean 36 years DU: mean 17 years S: 4 Canadian centers
Interventions P: 160 mg C: Flunarizine 10 mg
Outcomes R: 20/39 vs. 25/37 (patient global assessment; threshold used to define positive response not specified; denominators not fully clear, only percentages given) F: slightly better reduction with flunarizine AU: similar reduction HI: not reported AEs: 36/45 vs. 33/44 Dropouts‐AEs: 5/45 vs. 3/44 V: (‐)
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Unclear risk B ‐ Unclear