Mathew 1981‐Study 1

Methods	D: parallel C: unclear B: none WD: 67/340 J: 1‐0‐1 DU: 1m/6m/‐
Participants	N: 340/273 D: migraine (no interval headaches allowed) C: unclear F: 90% A: mean 35 years DU: not reported S: unclear, USA
Interventions	P: 120‐160 mg C1: No prophylactic therapy C2: Amitriptyline 50‐75 mg C3: Biofeedback C4: Propranolol + biofeedback C5: Amitriptyline + biofeedback C6: Amitriptyline + propranolol C7: Propranolol + amitriptyline + biofeedback
Outcomes	R: not reported F: not reported AU: not reported HI: index reduction 62% vs. 20% (C1), 42% (C2), 35% (C3), 64% (C4), 74% (C5), 48% (C6), 73% (C7) AEs: not reported Dropouts‐AEs: 1/44 (P) vs. 4/45 (C1) vs. 4/42 (C2) vs. 0/48 (C3) vs. 2/39 (C4) vs. 2/43 (C5) vs 2/41 (C6) vs. 3/38 (C7) V: + vs. C2
Notes	Uncommon 8‐armed trial Dropout rates highly variable between groups Only headache indices presented
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear