Mathew 1981‐Study 2

Methods	D: parallel C: unclear B: none WD: 94/375 J: 1‐0‐1 DU: 1m/6m/‐
Participants	N: 375/281 D: migraine + interval headaches C: unclear F: 95% A: mean 40 years DU: not reported S: unclear, USA
Interventions	P: 120‐160 mg C1: No prophylactic therapy C2: Amitriptyline 50‐75 mg C3: Biofeedback C4: Propranolol + biofeedback C5: Amitriptyline + biofeedback C6: Amitriptyline + propranolol C7: Propranolol + amitriptyline + biofeedback
Outcomes	R: not reported F: not reported AU: not reported HI: index reduction 52% vs. 18% (C1), 60% (C2), 48% (C3), 69% (C4), 62% (C5), 66% (C6), 76% (C7) AEs: not reported Dropouts‐AEs: 3/48 (P) vs. 9/49 (C1) vs. 3/44 (C2) vs. 1/52 (C3) vs. 3/43 (C4) vs. 4/46 (C5) vs. 2/47 (C6) vs. 4/46 (C7) V: (‐) vs. C2
Notes	Uncommon 8‐armed trial Dropout rates highly variable between groups Only headache indices presented
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear