Scholz 1987

Methods	D: parallel C: unclear B: double WD: 45/109 J: 1‐1‐0 DU: 8w/24w/3m
Participants	N: 83/83? (109 patients entered the study, 26 dropped out in the baseline period, 19 stopped treatment early ‐ not clear whether fully analyzed) D: 9 migraine with, 74 without aura C: unclear F: 77% A: mean 40 years DU: mean 19 years S: unclear, Germany
Interventions	P: 160 mg C1: Metoprolol 200 mg C2: Flunarizine 10 mg C3: Nifedipine 40 mg C4: Dihydroergotamine 10 mg
Outcomes	R: 33% vs. 60% vs. 17% vs. 31% vs. 8% (single case statistics) F: reduction of headache days by 30% vs. 54% vs. 11% vs. 5% vs. 37% AU: reduction by 40% vs. 40% vs. 41% vs. 45% vs. 33% HI: not reported AEs: not reported Dropouts‐AEs: 3/19 vs. 6/22 vs. 2/12 vs. 8/17 vs. 0/13 V: (‐) vs. C1, 0 vs. C2, 0 vs. C3, (+) vs. C4
Notes	Complex five‐armed trial Dropout reporting difficult to follow
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear