Comparison 4. Infections.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Seldinger (subclavian & IJ) versus venous cutdown (cephalic vein) ITT	6	906	Odds Ratio (M‐H, Fixed, 95% CI)	0.63 [0.25, 1.56]
2 Seldinger (subclavian vein) versus venous cutdown (cephalic vein) ITT	5	672	Odds Ratio (M‐H, Fixed, 95% CI)	0.85 [0.28, 2.58]
3 Seldinger (IJ vein) versus venous cutdown (cephalic vein) ITT	2	367	Odds Ratio (M‐H, Fixed, 95% CI)	0.27 [0.06, 1.34]
4 Seldinger (subclavian & IJ) versus venous cutdown (cephalic vein). On‐treatment analysis	6	838	Odds Ratio (M‐H, Fixed, 95% CI)	0.61 [0.24, 1.51]
5 Seldinger (subclavian vein) versus venous cutdown (cephalic vein). On‐treatment analysis	5	618	Odds Ratio (M‐H, Fixed, 95% CI)	0.79 [0.26, 2.40]
6 Seldinger (IJ vein) versus venous cutdown (cephalic vein). On‐treatment analysis	2	332	Odds Ratio (M‐H, Fixed, 95% CI)	0.27 [0.05, 1.30]