Table 1. Comparison between metrics in measurement of similarity between GTEx tissue-wide expression profiles of genes.

Similarity metric	Property 1 †, ‡	Property 2 †	Property 3 †
Bray-Curtis	√; [0,1]	√	√
Euclidean	√; (0,1]	√	×
Cosine	√; [0,1]	×	√
Pearson correlation 24	×; [-1,1]	×	×
Spearman correlation 25	×; [-1,1]	×	×

† The symbols √ and ×, respectively, indicate that the similarity metric satisfies and does not satisfy the property. ‡The interval in each cell indicates the range in which the result computed by the similarity metric lies.