Brown 2001.

Methods	Study design: Randomized controlled trial Country: USA Recruitment: Community volunteers Group size: not stated
Participants	179 smokers with history of MDD; 60% women, av. age 45, av. cpd 27 Therapists: 2 for each group, clinical psychologists
Interventions	1. Standard group therapy. 8 x 2 hrs over 6 wks, TQD session 5. Including nicotine fading, RP, homework 2. As 1. + CBT for depression. Same schedule + coping skills to control depressive symptoms
Outcomes	Sustained abstinence at 12 m (confirmed at post‐Rx, 1 m, 6 m). (PPA was main trial outcome) Validation: CO ≤ 10 ppm + saliva cotinine ≤ 46 ng/ml (abstinence was only verified by significant others in 6.5% of cases)
Notes	No non‐group control. Comparison 2.2.1 ‐ testing effect of depression/mood management programme. Direction of effect opposite for sustained and PPA
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomized, stratified on gender, current depressive symptoms, FTQ, using urn method
Allocation concealment (selection bias)	Low risk	No details given, but use of urn technique makes it likely that enrolment occurred before allocation known
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemical validation of abstinence
Incomplete outcome data (attrition bias) All outcomes	Low risk	8% lost to follow‐up at 12 m, included in ITT analysis