| Methods |
RCT, single centre, open, parallel group |
| Participants |
N = 29, acute GBS only
Adults only
No mild forms |
| Interventions |
Plasma exchange versus supportive care
3 to 5 plasma exchange, 3 L per plasma exchange, diluted albumin |
| Outcomes |
Hand‐grip force at 3 weeks after first plasma exchange |
| Notes |
‐ |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
There is no description of the method used for generating the allocation sequence |
| Allocation concealment (selection bias) |
High risk |
They used alternate allocation |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
The trial was not blinded |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
3/29 participants (1 in the experimental arm and 2 in the control arm) were excluded |
| Selective reporting (reporting bias) |
Unclear risk |
The authors did not provide the time to recover walking with aid or the proportion of participants with 1 or more disability grades' improvement at 1 month. The authors stated that the 2 groups were comparable after 1 year, but did not provide any data |
| Other bias |
Unclear risk |
Problems with diagnostic criteria and 3 participants did not have GBS, 1 had a form of relapsing polyradiculoneuritis and 2 other participants (1 in each group) had poliomyelitis |
