Comparison 3.

Samarium dose‐comparison (data as published)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain relief	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Complete relief (100%)	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
1.2 Complete/partial relief (50%‐100%)	1	103	Risk Ratio (M‐H, Random, 95% CI)	0.82 [0.59, 1.14]
1.3 Any amount of relief (1%‐100%)	1	103	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.74, 1.24]
2 Change in pain	1	103	Mean Difference (IV, Random, 95% CI)	2.73 [1.96, 3.50]
3 Analgesia consumption	1	102	Mean Difference (IV, Random, 95% CI)	‐1.0 [‐6.44, 4.44]
4 Fracture	1	114	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.23, 5.09]
5 Compression of spinal cord	2	193	Risk Ratio (M‐H, Random, 95% CI)	1.79 [0.54, 5.92]
6 Pain flares	2	185	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.47, 2.89]
7 Leucocytopenia III‐IV	2	178	Risk Ratio (M‐H, Random, 95% CI)	0.53 [0.12, 2.30]
8 Thrombocytopenia III‐IV	2	178	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.31, 2.01]
9 Anemia III‐IV	1	71	Risk Ratio (M‐H, Random, 95% CI)	1.46 [0.26, 8.21]
10 Death	2	184	Risk Ratio (M‐H, Random, 95% CI)	1.27 [0.63, 2.59]