Study	Reason for exclusion
De Klerk 1994	Dose‐escalation not randomised trial.
Dickie 1999	Controlled, not randomised trial.
Haesner 1992	Controlled, not randomised trial.
Liepe 2007	Controlled trial comparing 186Re, 186ReHEDP and 89Sr. There are no differences between intervention groups with respect to pain relief (81%, 77% and 80%) or leucocytopenia.
Loeb 2009	Dose‐escalation not randomised trial.
Malmberg 1997	Pain is not main outcome.
McEwan 1994	Retrospective cost‐benefit analysis of a subset of patients in Porter 1993. There are no differences between treatment and placebo groups in indirect costs or total inpatient stay costs. Costs related to tertiary in‐patient stay and to direct therapy are lower on the treatment group.
Morris 2009	Dose‐escalation not randomised trial.
Nilsson 2005	Radioisotopes compared to chemotherapy.
Oosterhof 2003	Radioisotopes compared to radiotherapy.
Parker 2009	Dose‐escalation randomised trial, pain is not main outcome.
Porfiri 2010	Chemotherapy alone or in combination with zoledronic acid (ZA) +/‐ 89Sr.
Quilty 1994	Radioisotopes compared to radiotherapy.
Storto 2006	Non‐randomised trial.
Tu 2001	Radioisotopes plus chemotherapy compared to chemotherapy.
Wang 2003	Radioisotopes compared to bisphosphonates.
Zafeirakis 2009	Dose‐escalation not randomised trial.
Zhang 2003	Dose‐escalation not randomised trial.