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Anti-HIV Data of Compounds 1−6
| compound | IC50a (μM) (MT4 cells) | CC50b (μM) (MT4 cells) | selectivity index (SI)c | statusd |
|---|---|---|---|---|
| 1 | − | − | − | I |
| 2 | − | − | − | I |
| 3 | 2.4 ± 0.1 | 12.6 ± 0.4 | 5.3 | A |
| 4 | − | − | − | I |
| 5 | − | − | − | I |
| 6 | 0.8 ± 0.1 | 4.6 ± 0.1 | 5.8 | A |
| AZTe | 0.014 ± 0.01 | >3.74 | >267.1 | A |
IC50 = 50% HIV inhibition concentration.
CC50 = 50% antiproliferative concentration.
Selectivity index (SI) = CC50/IC50; − = no selective anti-HIV activity (SI < 5).
A = active; I = inactive.
AZT: azidothymidine.
