Table 3.

Lung cancer susceptibility loci derived from GWAS, genetic risk specificity by subgroups, and suspected causal genes

Abbreviations: AD: adenocarcinoma; a: Asians; e: Europeans; m: men; n: never-smokers; o: older; s: smokers; SQ: squamous cell carcinoma; w: women; y: younger. The color of the background illustrates the strength of evidence on a black and white scale where black indicates convincing evidence and white indicates no evidence so far. The strength of evidence was assigned based on the content of publications cited in the first column and our best possible judgment and comprehension of each locus considering the number of studies that replicated the associations, the level of statistically significance, and the quality of the studies, e.g. sample size. No evidence (white) does not delineate the lack of associations that have been studied from those not yet examined and also highlights knowledge gaps.