| 1 Disability grade change after 4 weeks |
6 |
587 |
Mean Difference (IV, Random, 95% CI) |
0.36 [‐0.16, 0.88] |
| 1.1 Oral regimens |
4 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.82 [0.17, 1.47] |
| 1.2 Intravenous regimens |
2 |
467 |
Mean Difference (IV, Random, 95% CI) |
‐0.17 [‐0.39, 0.06] |
| 2 Improvement by ≥ 1 grades after 4 weeks |
5 |
567 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.08 [0.93, 1.24] |
| 2.1 Oral regimens |
3 |
100 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.80 [0.55, 1.16] |
| 2.2 Intravenous regimens |
2 |
467 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.14 [0.97, 1.34] |
| 3 Treatment vs. control OR for improvement by ≥ 1 grades by 4 weeks adjusted for age and initial disability grade |
2 |
|
log(OR) (Fixed, 95% CI) |
0.34 [‐0.05, 0.73] |
| 4 Death |
7 |
605 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.28 [0.67, 2.47] |
| 4.1 Oral regimens |
5 |
138 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.04 [0.41, 2.63] |
| 4.2 Intravenous regimens |
2 |
467 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.55 [0.61, 3.94] |
| 5 Death or disability after 1 year |
3 |
491 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.51 [0.91, 2.50] |
| 5.1 Oral regimens |
1 |
40 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.90 [0.14, 5.81] |
| 5.2 Intravenous regimens |
2 |
451 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.57 [0.93, 2.66] |
| 6 Disability grade change after 6 months |
2 |
455 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.36, 0.16] |
| 7 Disability grade change after 12 months |
3 |
471 |
Mean Difference (IV, Fixed, 95% CI) |
0.03 [‐0.23, 0.29] |
| 8 Proportion of participants who relapsed |
3 |
490 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.14 [0.59, 2.18] |
| 8.1 Oral regimens |
1 |
40 |
Risk Ratio (M‐H, Fixed, 95% CI) |
6.36 [0.35, 115.73] |
| 8.2 Intravenous regimens |
2 |
450 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.96 [0.48, 1.91] |
| 9 Adverse events |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 9.1 New infection treated with antibiotics |
2 |
467 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.74 [0.52, 1.04] |
| 9.2 Gastrointestinal haemorrhage |
2 |
467 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.17 [0.36, 3.78] |
| 9.3 Diabetes mellitus requiring insulin |
2 |
467 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.21 [1.19, 4.12] |
| 9.4 Hypertension |
2 |
467 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.15 [0.05, 0.41] |
