| Methods |
Open parallel‐group controlled trial with alternate allocation |
| Participants |
20 mostly adults with GBS defined according to criteria of Asbury 1990
|
| Interventions |
Intravenous methylprednisolone 1500 mg daily for 5 days versus supportive care |
| Outcomes |
Time to recovery: not significantly different between the 2 groups. After 6 months, 7 of 10 corticosteroid‐treated participants had returned to work or resumed domestic duties at 95% of normal. No adverse effects attributable to corticosteroids were reported |
| Funding |
Not stated |
| Conflicts of interest among primary investigators |
Not stated |
| Notes |
Single centre
Conducted in Mexico |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
High risk |
Alternate allocation |
| Allocation concealment (selection bias) |
High risk |
Alternate allocation |
| Blinding of participants and personnel (performance bias)
All outcomes except death |
High risk |
Control group received supportive care and no placebo |
| Blinding of participants and personnel (performance bias)
Death |
Low risk |
Reporting of death is unlikely to have been affected by inadequate blinding |
| Blinding of outcome assessment (detection bias)
All outcomes except death |
High risk |
Control group received supportive care and no placebo |
| Blinding of outcome assessment (detection bias)
Death |
Low risk |
Reporting of death is unlikely to have been affected by inadequate blinding |
| Incomplete outcome data (attrition bias)
All outcomes except death |
Low risk |
No drop‐outs were reported |
| Incomplete outcome data (attrition bias)
Death |
Low risk |
No drop‐outs were reported |
| Selective reporting (reporting bias) |
Low risk |
The only outcome described in the methods, the recovery curve, was reported |
| Other bias |
Unclear risk |
Insufficient information to judge |
