Skip to main content
. 2019 Apr 15;14(4):e0214708. doi: 10.1371/journal.pone.0214708

Table 2. MCMC-estimated parameter values for the infection MMs*.

Parameter (units) Poor efficacy Infection resistance p- value
Inoculum, VPCR(0) (vRNAmL) 102.2 [2.1, 2.3], (2.2) 102.1 [2, 2.3], (2.1) 0.248
Inoculum, VHEp−2(0) (PFUmL) 103.8 [3.8, 3.9], (3.8) 102.9 [2.6, 3.2], (2.9) <0.001
Inoculum, VSIAT(0) (TCID69mL) 10−0.09 [−0.38, 0.16], (−0.17) 10−0.1 [−0.38, 0.17], (−0.18) 0.490
SC rinse factor, Vpost-rinseVpre-rinse 10−2.3 [−2.5, −2.2], (−2.3) 10−2.2 [−2.4, −1.9], (−2.1) 0.136
Prod. rate, pPCR (vRNAmL·h) 104.8 [4.5, 5.6], (4.7) 104.5 [4.3, 4.7], (4.5) 0.050
Prod. rate, pHEp−2 (PFUmL·h) 105.4 [5.2, 6.2], (5.3) 105.1 [4.8, 5.3], (5) 0.014
Prod. rate, pSIAT (TCID69mL·h) 103.2 [3, 4], (3.1) 103 [2.8, 3.2], (2.9) 0.052
Infectiousness, β (mLPFU·h) 10−7.3 [−7.4, −7.1], (−7.2) 10−6.4 [−6.7, −6.2], (−6.4) <0.001
Eclipse phase, τE (days) 3.7 [3.1, 5.7], (3.5) 3 [2.5, 3.5], (2.8) 0.027
Virus-prod. phase, τI (days) 0.63 [0.45, 4.2], (3.6) 16 [9.5, ND], (15) <0.001
Antivir. timing, τF (days) 4.5 [3.5, 5.4], (4.5)
Derived (computed) parameters
Infecting time, tinf (h) 13 [4.9, 14], (13) 6.9 [5.4, 8.6], (7.5) 0.233
Infection rate, R0/τI (1/day) 1.1 [0.74, 7], (1.1) 3.6 [2.3, 6.1], (3.4) 0.233
Basic repro. num., R0 3.9 [3.1, 4.7], (3.9) 50 [26, ND], (50) <0.001
Sum Squared Resid., SSR 240 [230, 250], (230) 180 [170, 190], (170) <0.001
Akaike Inform. Crit., AICC 110 [100, 110], (100) 72 [67, 80], (65) <0.001

* Estimates are provided as: Mode [95% credible region] (best), where ‘best’ corresponds to the value of that parameter in the parameter set that yields the highest likelihood. A CR bound of ‘ND’ indicates the parameter is not bounded. The ‘Poor efficacy’ MM has 10 estimated parameters whereas the ‘Infection resistance’ MM has 11 (τF). This was taken into account in the calculation of the AICC. Parameters of the two age class MM for RSV infectivity loss MMs were fixed to the maximum likelihood values identified in Table 1 and thus are not included in the count of estimated parameters. The ‘Derived parameters’ were computed from the MM’s estimated parameters.