Table 1. Crude mortality rates per 1,000 person-years by individual antidepressant.
| Antidepressant | n | Deaths | Person-years (per 1,000) |
Mortality rate per 1,000 person-years (95% CI) |
|---|---|---|---|---|
| Overall | 376,846 | 27,019 | 225.81 | 119.7 (118.2–121.1) |
| SSRI | ||||
| Citalopram | 78,422 | 10,693 | 76.98 | 138.9 (136.3–141.6) |
| Escitalopram | 8,868 | 871 | 6.59 | 132.3 (123.6–141.3) |
| Sertraline | 11,897 | 1,621 | 13.93 | 116.4 (110.8–122.2) |
| Fluoxetine | 5,277 | 322 | 4.98 | 64.7 (57.8–72.2) |
| Paroxetine | 4,927 | 300 | 5.12 | 58.6 (52.2–65.6) |
| SSNRI | ||||
| Venlafaxine | 8,282 | 654 | 6.42 | 101.8 (94.2–109.9) |
| Duloxetine | 8,043 | 416 | 5.20 | 80.0 (72.5–88.1) |
| TCA | ||||
| Amitriptyline | 59,066 | 3,254 | 19.93 | 163.3 (157.7–169.0) |
| Doxepin | 27,837 | 645 | 7.24 | 89.1 (82.3–96.2) |
| Trimipramine | 23,480 | 343 | 5.12 | 66.9 (60.0–74.4) |
| Opipramol | 52,346 | 794 | 16.40 | 48.4 (45.1–51.9) |
| NASSA | ||||
| Mirtazapine | 69,714 | 6,692 | 42.61 | 157.1 (153.3–160.9) |
| Herbal AD | ||||
| St. John's wort | 18,687 | 414 | 15.29 | 27.1 (24.5–29.8) |
Abbreviation: AD, antidepressant; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic ADs; SSNRI, selective noradrenalin reuptake inhibitor; NASSA, noradrenergic and specific serotonergic Ads, CI, confidence interval