Table 3. Factors associated with non-completion of latent tuberculosis infection treatment.
590 contacts (close and frequent contacts) to whom treatment had been prescribed; contacts were detected through contact tracing of sputum smear-positive pulmonary tuberculosis cases. Barcelona 2008–2016.
| LTBI treatment | ||||||
|---|---|---|---|---|---|---|
| Non-completion | Completion | p-value** | OR | aOR | ||
| n = 72, n (%*) | n = 518, n (%*) | |||||
| Age | <40 years | 52 (13.3) | 338 (86.7) | 0.25 | 1 | |
| ≥40 years | 20 (10.1) | 179 (89.9) | 0.7 (0.4–1.3) | |||
| Sex | Man | 40 (12.1) | 291 (87.9) | 0.92 | 1 | |
| Woman | 32 (12.4) | 227 (87.6) | 1.0 (0.6–1.7) | |||
| Country of origin | Spain | 20 (8.3) | 222 (91.7) | 0.02 | 1 | 1 |
| Foreign-born | 50 (14.7) | 290 (85.3) | 1.9 (1.1–3.3) | 2.0 (1.0–3.7) | ||
| Type of contact | Close | 58 (11.4) | 452 (88.6) | 0.12 | 1 | |
| Frequent | 14 (17.5) | 66 (82.5) | 1.6 (0.9–3.1) | |||
| Setting | Home | 55 (10.9) | 449 (89.1) | 0.02 | 1 | 1 |
| Community | 17 (19.8) | 69 (80.2) | 2.0 (1.1–3.7) | 1.8 (0.8–3.9) | ||
| TST/IGRA Conversion | Yes | 4 (5.9) | 64 (94.1) | 0.09 | 1 | |
| No | 68 (13.0) | 454 (87.0) | 2.4 (0.8–6.8) | |||
| Smoking habit | No | 34 (10.1) | 303 (89.9) | 0.59 | 1 | |
| Yes | 16 (11.8) | 120 (88.2) | 1.2 (0.6–2.2) | |||
| DM | No | 48 (10.1) | 428 (89.9) | 0.25 | 1 | |
| Yes | 5 (16.7) | 25 (83.3) | 1.8 (0.6–4.9) | |||
| HIV infection | No | 53 (10.4) | 456 (89.6) | 0.07 | 1 | |
| Yes | 1 (50.0) | 1 (50.0) | 8.6 (0.5–139.6) | |||
| Alcohol abuse | No | 48 (11.0) | 389 (89.0) | 0.53 | 1 | |
| Yes | 2 (7.1) | 26 (92.9) | 0.6 (0.1–2.7) | |||
LTBI: latent tuberculosis infection; OR: odds ratio; aOR: odds ratio adjusted by country of origin and setting of contact; TST/IGRA conversion: conversion in tuberculin screen test or IGRA seroconversion; DM: diabetes mellitus.
*Percentage over the total without missing values;
**p-value for the univariate analyses;.