Summary of findings for the main comparison. Propofol compared to Thiopental sodium for the treatment of refractory status epilepticus.

Propofol compared to Thiopental sodium for the treatment of refractory status epilepticus
Patient or population: patients with the treatment of refractory status epilepticus Settings: Hospital based Intervention: Propofol Comparison: Thiopental sodium
Outcomes	Illustrative comparative risks* (95% CI)		Relative effect (95% CI)	No of Participants (studies)	Quality of the evidence (GRADE)	Comments
	Assumed risk	Corresponding risk
	Thiopental sodium	Propofol
Total control of seizures	Study population		RR 1.5 (0.4 to 5.61)	21 (1 study)	⊕⊕⊝⊝ low1,2
	286 per 1000	429 per 1000 (114 to 1000)
In‐hospital mortality	Study population		RR 1.5 (0.19 to 11.93)	21 (1 study)	⊕⊕⊝⊝ low1,2
	143 per 1000	214 per 1000 (27 to 1000)
Length of intensive care unit (ICU) stay	Not reported	Not reported	NA	NA	NA
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio;
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.

¹ Single blinded study: we downgraded one level for risk of bias
 ² Wide confidence intervals crossing the line of "no effect" were noted; we downgraded one level for imprecision