Summary of findings for the main comparison. Fluid restricted compared to liberal fluids compared to placebo for treatment of preterm babies with chronic lung disease.
| Fluid restricted compared to liberal fluids compared to placebo for treatment of preterm babies with chronic lung disease | ||||||
| Participant or population: treatment of preterm babies with chronic lung disease Setting: Intervention: Fluid restricted compared to liberal fluids Comparison: placebo | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with placebo | Risk with fluid restricted compared to liberal fluids | |||||
| Duration of oxygen therapy | The mean duration of oxygen therapy was 27.5 days | median 0.5 days higher (0 to 0 ) | ‐ | 60 (1 RCT) | ⊕⊕⊝⊝ LOW 1 2 | |
| Duration of hospitalisation | The mean duration of hospitalisation was 85 days | MD 3 Days higher (7.64 lower to 13.64 higher) | ‐ | 60 (1 RCT) | ⊕⊕⊝⊝ LOW 1 2 | |
| Daily weight gain | The mean daily weight gain was 14.8 g/kg/d | MD 0.5 g/kg/d higher (1.22 lower to 2.22 higher) | ‐ | 60 (1 RCT) | ⊕⊕⊝⊝ LOW 1 2 | |
| Proportion with apnoea | Study population | RR 1.35 (0.98 to 1.86) | 60 (1 RCT) | ⊕⊕⊝⊝ LOW 1 2 | ||
| 630 per 1000 | 850 per 1000 (617 to 1000) | |||||
| Moderate | ||||||
| 630 per 1000 | 850 per 1000 (617 to 1000) | |||||
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect | ||||||
1 Unmasked study
2 Wide confidence limits