4. Ranking probabilities of different interventions.
Mortality at maximal follow‐up | ||||||||||||
Rank | Tac | Cy | Cy_Aza | Cy_Aza_Std | Cy_Myc_Std | Cy_Std | Ever | Tac_Aza | Tac_Ever | Tac_Myc_Std | Tac_Sir | Tac_Std |
1 | 0.002 | 0.001 | 0.0081 | 0.0059 | 0.0429 | 0.08883 | 0.003833 | 0.4588 | 0.01477 | 0.2413 | 0.002833 | 0.1298 |
2 | 0.02697 | 0.0091 | 0.02223 | 0.0205 | 0.01723 | 0.1636 | 0.01063 | 0.1413 | 0.03433 | 0.2943 | 0.0058 | 0.254 |
3 | 0.06937 | 0.03153 | 0.0344 | 0.01453 | 0.02043 | 0.2026 | 0.0175 | 0.1347 | 0.04107 | 0.1896 | 0.007833 | 0.2364 |
4 | 0.1398 | 0.07723 | 0.05383 | 0.02217 | 0.02243 | 0.2261 | 0.02603 | 0.1165 | 0.06163 | 0.1054 | 0.0107 | 0.1381 |
5 | 0.2622 | 0.1618 | 0.0916 | 0.02023 | 0.0251 | 0.1223 | 0.0448 | 0.04737 | 0.089 | 0.05653 | 0.0152 | 0.0638 |
6 | 0.2462 | 0.2478 | 0.0984 | 0.01667 | 0.01947 | 0.0837 | 0.06113 | 0.03437 | 0.08167 | 0.0391 | 0.02023 | 0.05127 |
7 | 0.1561 | 0.2136 | 0.1886 | 0.01463 | 0.0179 | 0.04797 | 0.1067 | 0.022 | 0.1217 | 0.02753 | 0.03773 | 0.04547 |
8 | 0.0698 | 0.1476 | 0.1823 | 0.02453 | 0.02297 | 0.03197 | 0.1922 | 0.017 | 0.1797 | 0.02253 | 0.07307 | 0.03623 |
9 | 0.02213 | 0.0767 | 0.1805 | 0.0347 | 0.03257 | 0.0216 | 0.2746 | 0.01443 | 0.1841 | 0.0163 | 0.1118 | 0.03067 |
10 | 0.004433 | 0.02673 | 0.0916 | 0.073 | 0.05803 | 0.0086 | 0.1729 | 0.0083 | 0.1261 | 0.006067 | 0.4119 | 0.0123 |
11 | 0.000867 | 0.005967 | 0.038 | 0.3902 | 0.309 | 0.002 | 0.06763 | 0.0036 | 0.04383 | 0.001 | 0.1366 | 0.001367 |
12 | 6.67E‐05 | 0.000933 | 0.01047 | 0.363 | 0.412 | 0.0007 | 0.02197 | 0.001633 | 0.02207 | 0.0003 | 0.1663 | 0.0006 |
Graft loss at maximal follow‐up | ||||||||||||
Rank | Tac | Cy | Cy_Aza | Ever | Tac_Aza | Tac_Ever | Tac_Myc_Std | Tac_Sir | Tac_Std | |||
1 | 0.01193 | 0.007067 | 0.0211 | 0.05607 | 0.4405 | 0.05217 | 0.1118 | 0.017 | 0.2823 | |||
2 | 0.08647 | 0.02727 | 0.04603 | 0.097 | 0.1568 | 0.08173 | 0.2609 | 0.02827 | 0.2156 | |||
3 | 0.165 | 0.05783 | 0.06317 | 0.09837 | 0.1764 | 0.09153 | 0.1978 | 0.03217 | 0.1177 | |||
4 | 0.3136 | 0.1072 | 0.09 | 0.1128 | 0.06527 | 0.1136 | 0.0911 | 0.03983 | 0.06663 | |||
5 | 0.2383 | 0.1876 | 0.1108 | 0.1145 | 0.04677 | 0.1211 | 0.07753 | 0.04807 | 0.0552 | |||
6 | 0.1362 | 0.2272 | 0.1466 | 0.1295 | 0.03837 | 0.1243 | 0.07083 | 0.0675 | 0.05943 | |||
7 | 0.0397 | 0.2128 | 0.1777 | 0.1418 | 0.03157 | 0.149 | 0.07553 | 0.1117 | 0.06023 | |||
8 | 0.007867 | 0.1347 | 0.2162 | 0.1517 | 0.02537 | 0.1572 | 0.07533 | 0.1598 | 0.07187 | |||
9 | 0.0009 | 0.0383 | 0.1283 | 0.09827 | 0.01893 | 0.1094 | 0.03913 | 0.4957 | 0.07107 | |||
Adverse events (proportion) | ||||||||||||
Rank | Tac | Ever | Tac_Ever | Tac_Sir | ||||||||
1 | 0.269 | 0.4943 | 0.1828 | 0.05393 | ||||||||
2 | 0.3693 | 0.302 | 0.3059 | 0.02283 | ||||||||
3 | 0.3366 | 0.1819 | 0.4476 | 0.03387 | ||||||||
4 | 0.0251 | 0.02177 | 0.06377 | 0.8894 | ||||||||
Adverse events (number) | ||||||||||||
Rank | Tac | Cy | Cy_Std | Ever | Tac_Myc | Tac_Myc_Std | ||||||
1 | 0 | 0.3396 | 0.001967 | 0.6566 | 0.0008 | 0.001067 | ||||||
2 | 0.07187 | 0.6552 | 0.03233 | 0.2176 | 0.0061 | 0.01687 | ||||||
3 | 0.6274 | 0.0051 | 0.1901 | 0.05377 | 0.02423 | 0.09947 | ||||||
4 | 0.2581 | 6.67E‐05 | 0.3336 | 0.0368 | 0.03877 | 0.3327 | ||||||
5 | 0.03857 | 0 | 0.3133 | 0.0218 | 0.1179 | 0.5085 | ||||||
6 | 0.0041 | 0 | 0.1288 | 0.01347 | 0.8122 | 0.04143 | ||||||
Renal impairment | ||||||||||||
Rank | Tac | Cy | Cy_Aza_Std | Ever | Tac_Ever | Tac_Myc | Tac_Myc_Std | Tac_Std | ||||
1 | 0.0153 | 0.0404 | 0.504 | 0.1631 | 0.04607 | 0.08963 | 0.1122 | 0.0293 | ||||
2 | 0.0536 | 0.08217 | 0.08977 | 0.1705 | 0.0753 | 0.131 | 0.2908 | 0.1069 | ||||
3 | 0.1178 | 0.1174 | 0.05827 | 0.1112 | 0.0959 | 0.1464 | 0.2312 | 0.1219 | ||||
4 | 0.1731 | 0.1524 | 0.049 | 0.1023 | 0.0912 | 0.1429 | 0.1471 | 0.142 | ||||
5 | 0.2275 | 0.1838 | 0.0433 | 0.1099 | 0.1023 | 0.1152 | 0.09747 | 0.1204 | ||||
6 | 0.2333 | 0.1717 | 0.0468 | 0.0993 | 0.1192 | 0.1216 | 0.0716 | 0.1364 | ||||
7 | 0.1358 | 0.1452 | 0.064 | 0.1444 | 0.1694 | 0.115 | 0.03967 | 0.1866 | ||||
8 | 0.04363 | 0.1069 | 0.1449 | 0.09933 | 0.3006 | 0.1382 | 0.01 | 0.1565 | ||||
Retransplantation | ||||||||||||
Rank | Tac | Cy | Cy_Aza | Cy_Aza_Std | Tac_Aza | Tac_Myc | Tac_Myc_Std | Tac_Std | ||||
1 | 0.0925 | 0.002667 | 0.04833 | 0.1566 | 0.3022 | 0.0076 | 0.1543 | 0.2358 | ||||
2 | 0.2075 | 0.01133 | 0.06863 | 0.06533 | 0.146 | 0.01023 | 0.247 | 0.244 | ||||
3 | 0.2234 | 0.04117 | 0.1197 | 0.0679 | 0.1452 | 0.0175 | 0.2247 | 0.1604 | ||||
4 | 0.2633 | 0.0855 | 0.1304 | 0.04907 | 0.1466 | 0.02703 | 0.17 | 0.128 | ||||
5 | 0.1688 | 0.1677 | 0.1941 | 0.0683 | 0.1204 | 0.0381 | 0.1317 | 0.1109 | ||||
6 | 0.03903 | 0.3206 | 0.2627 | 0.07923 | 0.08443 | 0.06377 | 0.0573 | 0.09293 | ||||
7 | 0.005133 | 0.3006 | 0.1444 | 0.2519 | 0.0407 | 0.2169 | 0.01447 | 0.02593 | ||||
8 | 0.000267 | 0.07043 | 0.03177 | 0.2617 | 0.01447 | 0.6188 | 0.000467 | 0.0021 | ||||
Graft rejections (any) | ||||||||||||
Rank | Tac | Cy | Cy_Aza | Cy_Aza_Std | Cy_Myc | Cy_Std | Ever | Tac_Aza | Tac_Ever | Tac_Myc | Tac_Myc_Std | Tac_Std |
1 | 0.0015 | 0.0003 | 0.0619 | 0.0906 | 0.05987 | 0.05883 | 0.004033 | 0.01077 | 0.4311 | 0.09627 | 0.1642 | 0.02063 |
2 | 0.01683 | 0.002133 | 0.109 | 0.0657 | 0.0654 | 0.1025 | 0.01983 | 0.0222 | 0.1711 | 0.1295 | 0.2467 | 0.049 |
3 | 0.06013 | 0.0061 | 0.1157 | 0.0591 | 0.07787 | 0.132 | 0.02767 | 0.02877 | 0.1165 | 0.1298 | 0.1887 | 0.05763 |
4 | 0.1338 | 0.01607 | 0.1119 | 0.05787 | 0.0811 | 0.132 | 0.0359 | 0.03733 | 0.0984 | 0.1032 | 0.1329 | 0.0595 |
5 | 0.1982 | 0.04087 | 0.1146 | 0.05963 | 0.06117 | 0.1265 | 0.04947 | 0.04803 | 0.06617 | 0.0829 | 0.08977 | 0.0626 |
6 | 0.2194 | 0.08913 | 0.09947 | 0.05347 | 0.05667 | 0.1176 | 0.06387 | 0.0616 | 0.0371 | 0.0738 | 0.06087 | 0.06703 |
7 | 0.1777 | 0.1456 | 0.0916 | 0.05317 | 0.05853 | 0.1059 | 0.07933 | 0.08 | 0.02787 | 0.06903 | 0.03907 | 0.0722 |
8 | 0.1129 | 0.2133 | 0.0809 | 0.06043 | 0.06207 | 0.07973 | 0.09677 | 0.0964 | 0.01973 | 0.06597 | 0.03097 | 0.08087 |
9 | 0.05737 | 0.2036 | 0.0736 | 0.07683 | 0.06823 | 0.065 | 0.1299 | 0.1193 | 0.01433 | 0.07087 | 0.02283 | 0.09813 |
10 | 0.0187 | 0.1639 | 0.05877 | 0.08767 | 0.09003 | 0.05113 | 0.1546 | 0.1526 | 0.009267 | 0.07103 | 0.01567 | 0.1267 |
11 | 0.003133 | 0.09203 | 0.04827 | 0.1311 | 0.1047 | 0.02003 | 0.1594 | 0.1606 | 0.006167 | 0.08387 | 0.0063 | 0.1844 |
12 | 0.000267 | 0.02697 | 0.03423 | 0.2044 | 0.2143 | 0.008733 | 0.1793 | 0.1824 | 0.002267 | 0.0238 | 0.001933 | 0.1213 |
Graft rejections requiring treatment | ||||||||||||
Rank | Tac | Cy | Cy_Std | Ever | Tac_Ever | |||||||
1 | 0.07247 | 0.06747 | 0.1412 | 0.0279 | 0.691 | |||||||
2 | 0.4076 | 0.236 | 0.1216 | 0.08197 | 0.1527 | |||||||
3 | 0.3061 | 0.3952 | 0.1103 | 0.1127 | 0.07577 | |||||||
4 | 0.1736 | 0.2476 | 0.1811 | 0.3476 | 0.0502 | |||||||
5 | 0.04017 | 0.05377 | 0.4459 | 0.4299 | 0.0303 |
Abbreviations: Tac = tacrolimus; Cy = cyclosporine A; Myc = mycophenolate; Aza = azathioprine; Sir = sirolimus; Ever = everolimus; Std = glucocorticosteroids; _ = plus