Database	Time span	Search strategy
The Central Register of Controlled Trials (CENTRAL) in the Cochrane Library	Issue 10, 2016	#1 (liver or hepatic) #2 (transplant* or graft*) #3 #1 and #2 #4 MeSH descriptor: [Liver Transplantation] explode all trees #5 #3 or #4 #6 immunosuppress* #7 MeSH descriptor: [Immunosuppression] explode all trees #8 MeSH descriptor: [Immunosuppressive Agents] explode all trees #9 #6 or #7 or #8 #10 MeSH descriptor: [Cyclosporine] explode all trees #11 MeSH descriptor: [Tacrolimus] explode all trees #12 MeSH descriptor: [Antimetabolites] explode all trees #13 MeSH descriptor: [Sirolimus] explode all trees #14 MeSH descriptor: [Glucocorticoids] explode all trees #15 MeSH descriptor: [Antilymphocyte Serum] explode all trees #16 (Calcineurin inhibitor* or cyclosporine* or ciclosporin* or tacrilimus or antimetabolite or mycophenolate or azathioprine or mTOR inhibitor* or sirolimus or rapamycin or everolimus or corticosteroids or glucocorticoids or prednisolone or prednisone or methylprednisolone or cortisol or cortisone or methylprednisolone or betamethasone or thymoglobulin or antithymocyte or antilymphocyte or anti‐thymocyte or thymocyte antibody or anti‐lymphocyte or alemtuzumab or basiliximab or daclizumab) #17 #10 or #11 or #12 or #13 or #14 or #15 or #16 #18 #5 and #9 and #17
MEDLINE (OvidSP)	January 1947 to October 2016	1. (liver or hepatic).af. 2. (transplant* or graft*).af. 3. 1 and 2 4. exp Liver Transplantation/ 5. 3 or 4 6. exp Immunosuppression/ or exp Immunosuppressive Agents/ 7. immunosuppress*.ti,ab. 8. 6 or 7 9. exp Cyclosporine/ 10. exp Tacrolimus/ 11. exp Antimetabolites/ 12. exp Sirolimus/ 13. exp Glucocorticoids/ 14. exp Antilymphocyte Serum/ 15. (Calcineurin inhibitor* or cyclosporine* or ciclosporin* or tacrilimus or antimetabolite or mycophenolate or azathioprine or mTOR inhibitor* or sirolimus or rapamycin or everolimus or corticosteroids or glucocorticoids or prednisolone or prednisone or methylprednisolone or cortisol or cortisone or methylprednisolone or betamethasone or thymoglobulin or antithymocyte or antilymphocyte or anti‐thymocyte or thymocyte antibody or anti‐lymphocyte or alemtuzumab or basiliximab or daclizumab).ti,ab. 16. or/9‐15 17. 5 and 8 and 16 18. randomized controlled trial.pt. 19. controlled clinical trial.pt. 20. randomized.ab. 21. placebo.ab. 22. drug therapy.fs. 23. randomly.ab. 24. trial.ab. 25. groups.ab. 26. 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 27. exp animals/ not humans.sh. 28. 26 not 27 29. 17 and 28
Embase (OvidSP)	January 1974 to October 2016	1. (liver or hepatic).af. 2. (transplant* or graft*).af. 3. 1 and 2 4. exp liver transplantation/ 5. 3 or 4 6. exp immunosuppressive treatment/ or exp immunosuppressive agent/ 7. immunosuppress*.ti,ab. 8. 6 or 7 9. exp calcineurin inhibitor/ 10. exp antimetabolite/ 11. exp rapamycin/ or exp everolimus/ 12. exp glucocorticoid/ 13. exp thymocyte antibody/ 14. (Calcineurin inhibitor* or cyclosporine* or ciclosporin* or tacrilimus or antimetabolite or mycophenolate or azathioprine or mTOR inhibitor* or sirolimus or rapamycin or everolimus or corticosteroids or glucocorticoids or prednisolone or prednisone or methylprednisolone or cortisol or cortisone or methylprednisolone or betamethasone or thymoglobulin or antithymocyte or antilymphocyte or anti‐thymocyte or thymocyte antibody or anti‐lymphocyte or alemtuzumab or basiliximab or daclizumab).ti,ab. 15. or/9‐14 16. 5 and 8 and 15 17. exp crossover‐procedure/ or exp double‐blind procedure/ or exp randomized controlled trial/ or single‐blind procedure/ 18. (((((random* or factorial* or crossover* or cross over* or cross‐over* or placebo* or double*) adj blind*) or single*) adj blind*) or assign* or allocat* or volunteer*).af. 19. 17 or 18 20. 16 and 19
Science Citation Index Expanded (Web of Knowledge)	January 1945 to October 2016	#1 TS=((liver or hepatic) AND (transplant* or graft*)) #2 TS=(immunosuppress*) #3 TS=(Calcineurin inhibitor* or cyclosporine* or ciclosporin* or tacrilimus or antimetabolite or mycophenolate or azathioprine or mTOR inhibitor* or sirolimus or rapamycin or everolimus or corticosteroids or glucocorticoids or prednisolone or prednisone or methylprednisolone or cortisol or cortisone or methylprednisolone or betamethasone or thymoglobulin or antithymocyte or antilymphocyte or anti‐thymocyte or thymocyte antibody or anti‐lymphocyte or alemtuzumab or basiliximab or daclizumab) #4 TS=(random* OR rct* OR crossover OR masked OR blind* OR placebo* OR meta‐analysis OR systematic review* OR meta‐analys*) #5 #1 and #2 and #3 and #4
World Health Organization International Clinical Trials Registry Platform (apps.who.int/trialsearch/Default.aspx)	October 2016	liver transplant* AND immunosuppress*
ClinicalTrials.gov	October 2016	Interventional Studies | liver transplant* | immunosuppression | Phase 2, 3, 4