Summary of findings 3. Colchicine compared with no intervention for alcoholic hepatitis (all severity).
| Colchicine compared with no intervention for alcoholic hepatitis (all severity) | |||||
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Patient or population: participants with alcoholic hepatitis (all severity) Settings: secondary or tertiary care Intervention: colchicine Comparison: no intervention | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (trials) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| No intervention | Colchicine | ||||
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Mortality at maximal follow‐up Follow‐up: 3 to 4 months |
348 per 1000 | 86 per 1000 (32 to 206) | OR 1.31 (0.47 to 3.64) | 139 (2 trials) | ⊕⊝⊝⊝ very low1,2,3 |
| Early mortality (mortality up to 90 days) | 217 per 1000 | 185 per 1000 (9 to 853) | OR 3.18 (0.13 to 81.01) | 69 (1 trial) | ⊕⊝⊝⊝ very low1,2,3 |
| Serious adverse events (proportion) | None of the trials reported this outcome. | ||||
| Serious adverse events (number) | None of the trials reported this outcome. | ||||
| Health‐related quality of life | None of the trials reported this outcome. | ||||
| *The basis for the assumed risk is the mean control group risk across studies. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio. | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1Risk of bias: trial(s) were at high risk of bias (downgraded one level)
2Imprecision: small sample size (downgraded one level)
3Imprecision: Confidence intervals overlapped a clinically significant increase or reduction and clinically insignificant increase or reduction (downgraded one level).