Summary of findings 11. Propylthiouracil compared with no intervention for alcohol‐related disorders (others).
| Propylthiouracil compared with no intervention for alcohol‐related disorders (others) | |||||
|
Patient or population: alcohol‐related disorders (others) Settings: secondary or tertiary care Intervention: propylthiouracil Comparison: no intervention | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (trials) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| No intervention | Propylthiouracil | ||||
|
Mortality at maximal follow‐up Follow‐up: 1 to 24 months |
252 per 1000 | 132 per 1000 (81 to 208) | OR 0.45 (0.26 to 0.78) | 423 (2 trials) | ⊕⊕⊝⊝ low1,2 |
| Early mortality (mortality up to 90 days) | None of the trials reported this outcome. | ||||
| Serious adverse events (proportion) | None of the trials reported this outcome. | ||||
| Serious adverse events (number) | None of the trials reported this outcome. | ||||
| Health‐related quality of life | None of the trials reported this outcome. | ||||
| *The basis for the assumed risk is the mean control group risk across studies. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio. | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1Risk of bias: trial(s) were at high risk of bias (downgraded one level)
2Imprecision: small sample size (downgraded one level)
3Imprecision: Confidence intervals overlapped a clinically significant increase or reduction and clinically insignificant increase or reduction (downgraded one level).