Comparison 2. Treatment of RDS with CCSP versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Chronic lung disease (need for oxygen or respiratory support at 36 weeks' postmenstrual age)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 rhCC10 dose = 1.5 mg/kg	1	14	Risk Ratio (M‐H, Fixed, 95% CI)	0.5 [0.06, 4.33]
1.2 rhCC10 dose = 5 mg/kg	1	13	Risk Ratio (M‐H, Fixed, 95% CI)	1.75 [0.42, 7.23]
2 Mortality prior to hospital discharge	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 rhCC10 dose = 1.5 mg/kg	1	15	Risk Ratio (M‐H, Fixed, 95% CI)	2.67 [0.13, 56.63]
2.2 rhCC10 dose = 5 mg/kg	1	14	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.14, 63.15]
3 Chronic lung disease (need for oxygen or respiratory support at 28 days of age)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 rhCC10 dose = 1.5 mg/kg	1	14	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.78, 1.29]
3.2 rhCC10 dose = 5 mg/kg	1	13	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.55, 1.28]
4 Necrotising enterocolitis	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 rhCC10 dose = 1.5 mg/kg	1	15	Risk Ratio (M‐H, Fixed, 95% CI)	4.44 [0.25, 79.42]
4.2 rhCC10 dose = 5 mg/kg	1	14	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.14, 63.15]
5 Intraventricular haemorrhage (any grade)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 rhCC10 dose = 1.5 mg/kg	1	15	Risk Ratio (M‐H, Fixed, 95% CI)	0.18 [0.01, 3.18]
5.2 rhCC10 dose = 5 mg/kg	1	14	Risk Ratio (M‐H, Fixed, 95% CI)	0.5 [0.06, 4.33]
6 Periventricular leukomalacia	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 rhCC10 dose = 1.5 mg/kg	1	15	Risk Ratio (M‐H, Fixed, 95% CI)	0.30 [0.01, 6.29]
6.2 rhCC10 dose = 5 mg/kg	1	14	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.02, 7.02]
7 Culture‐proven sepsis	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 rhCC10 dose = 1.5 mg/kg	1	15	Risk Ratio (M‐H, Fixed, 95% CI)	2.67 [0.13, 56.63]
7.2 rhCC10 dose = 5 mg/kg	1	14	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.14, 63.15]
8 Patent ductus arteriosus	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 rhCC10 dose = 1.5 mg/kg	1	15	Risk Ratio (M‐H, Fixed, 95% CI)	0.53 [0.19, 1.44]
8.2 rhCC10 dose = 5 mg/kg	1	14	Risk Ratio (M‐H, Fixed, 95% CI)	0.4 [0.11, 1.41]
9 Days of mechanical ventilation	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
9.1 rhCC10 dose = 1.5 mg/kg	1	15	Mean Difference (IV, Fixed, 95% CI)	‐3.40 [‐11.98, 5.18]
9.2 rhCC10 dose = 5 mg/kg	1	14	Mean Difference (IV, Fixed, 95% CI)	12.0 [0.39, 23.61]
10 Days of supplemental oxygen administration	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
10.1 rhCC10 dose = 1.5 mg/kg	1	15	Mean Difference (IV, Fixed, 95% CI)	‐7.60 [‐17.98, 2.78]
10.2 rhCC10 dose = 5 mg/kg	1	14	Mean Difference (IV, Fixed, 95% CI)	‐1.60 [‐18.05, 14.85]