Jacques 1995.

Methods	RCT of parallel group design.
Participants	155 participants (men and women, 20 to 65 years old) were recruited and screened between December 1989 and September 1991 from two sources in Boston. Employees of a large manufacturing complex were recruited by work site posters and presentations, and Boston area residents were recruited by printed advertisements. Exclusion criteria: · Age ˂ 20 or > 65 years · Plasma ascorbic acid > 80 µmol/L for men or > 90 µmol/L for women · HDL cholesterol > 1.4 mmol/L for men or >1.7 mmol/L for women · Total cholesterol > 6.7 mmol/L · Body mass index > 31 kg/m2 for men or > 33 kg/m2 for women · Current smokers · History of diabetes, heart disease or liver disease · Vitamin C supplement use (> 60 mg/day) within the last 3 months · Use of lipid altering medication · On a weight modifying diet
Interventions	Intervention (n = 80): 2 x 500 mg vitamin C tablets per day (one each morning and one each evening) for 8 months. Control (n = 75): 2 x placebo tablets per day (one each morning and one each evening) for 8 months.
Outcomes	Total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides.
Notes	Funding: commercial and non‐commercial (Hoffman‐La Roche and US Department of Agriculture).
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated.
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	States "double‐blind" but provide no further details.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not stated.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Numbers lost to follow‐up provided, and reasons for exclusions provided.
Selective reporting (reporting bias)	Low risk	All outcomes reported as specified.
Other bias	Unclear risk	Insufficient information to judge Non‐commercial and commercial funding. Authors did state that the content of the study does not necessarily represent the views of the US Department of Agriculture.