1. Polypill content by trial.

Study	Polypill contents (dose)	Comparator
CRUCIAL 2011	Amlodipine 5 mg to 10 mg Atorvastatin 10 mga	Usual care
CUSP 2009	Amlodipine 5 mg Atorvastatin 20 mg	Placebo
FOCUS 2014	Aspirin 100 mg Ramipril 2.5 mg, 5 mg, or 10 mg Simvastatin 40 mg	Individual components: Aspirin 100 mg Ramipril 2.5 mg, 5 mg, or 10 mg Simvastatin 40 mg
IMPACT 2014	Aspirin 75 mg Atenolol 50 mg Lisinopril 10 mg Simvastatin 40 mg or Aspirin 75 mg Hydrochlorothiazide 12.5 mg Lisinopril 10 mg Simvastatin 4 0mg	Usual care
Kanyini GAP 2014	Aspirin 75 mg Atenolol 50 mg Lisinopril 10 mg Simvastatin 40 mg or Aspirin 75 mg Hydrochlorothiazide 12.5 mg Lisinopril 10 mg Simvastatin 40 mg	Usual care
Malekzadeh 2010	Aspirin 81 mg Atorvastatin 20 mg Enalapril 2.5 mg Hydrochlorothiazide 12.5 mg	Placebo
OLSTA 2016	Olmesartan 40 mg Rosuvastatin 20 mg	Olmesartan 40 mg, rosuvastatin 20 mg, or placebo
PILL 2011	Aspirin 75 mg Hydrochlorothiazide 12.5 mg Lisinopril 10 mg Simvastatin 20 mg	Placebo
Soliman 2009	Aspirin 75 mg Hydrochlorothiazide 12.5 mg Lisinopril 10 mg Simvastatin 20 mg	Usual care
TIPS 2009	Aspirin 100 mg Atenolol 50 mg Hydrochlorothiazide 12.5 mg Ramipril 5 mg Simvastatin 20 mg	8 other drug/drug combination groups: Aspirin 100 mg Aspirin 100 mg, hydrochlorothiazide 12.5 mg, atenolol 50 mg, ramipril 5 mg Hydrochlorothiazide 12.5 mg Hydrochlorothiazide 12.5 mg, atenolol 50 mg Hydrochlorothiazide 12.5 mg, ramipril 5 mg Hydrochlorothiazide 12.5 mg, atenolol 50 mg, ramipril 5 mg Ramipril 5 mg, atenolol 50 mg, or Simvastatin 20 mg
TOGETHER 2010	Amlodipine 5 mg to 10 mg Atorvastatin 10 mg	Amlodipine 5 mg, 10 mg
UMPIRE 2013	Aspirin 75 mg Atenolol 50 mg Lisinopril 10 mg Simvastatin 40 mg or Aspirin 75 mg Hydrochlorothiazide 12.5 mg Lisinopril 10 mg Simvastatin 40 mg	Usual care
Wald 2012	Amlodipine 2.5 mg Hydrochlorothiazide 12.5 mg Losartan 25 mg Simvastatin 40 mg	Placebo

^aSite investigators could request dosages of amlodipine and atorvastatin 5/20 mg and 10/20 mg.