Comparison 1. Mortality and cardiovascular events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	5	5300	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.64, 1.89]
2 All‐cause mortality: comparator as usual care	4	4601	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.64, 1.91]
3 All‐cause mortality: comparator provision of individual drugs	1	699	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.06, 15.88]
4 All‐cause mortality: 3+ drugs	4	3839	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.56, 1.78]
5 All‐cause mortality: 2+ drugs	1	1461	Risk Ratio (M‐H, Fixed, 95% CI)	2.19 [0.43, 11.24]
6 Fatal or non‐fatal ASCVD events	6	4517	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [0.95, 1.66]
7 Fatal and non‐fatal ASCVD events: primary prevention trials	2	686	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.04, 3.23]
8 Fatal and non‐fatal ASCVD events: secondary prevention trials	4	3831	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.97, 1.72]
9 Fatal and non‐fatal ASCVD events: comparator provision of individual drugs	2	906	Risk Ratio (M‐H, Fixed, 95% CI)	1.63 [0.66, 3.98]
10 Fatal and non‐fatal ASCVD events: comparator as usual care	4	3611	Risk Ratio (M‐H, Fixed, 95% CI)	1.22 [0.91, 1.64]
11 Fatal and non‐fatal ASCVD events: 3+ drugs	5	4306	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.96, 1.69]
12 Fatal and non‐fatal ASCVD events: 2 drugs	1	211	Risk Ratio (M‐H, Fixed, 95% CI)	0.39 [0.02, 8.05]