Comparison 3. Blood pressure.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systolic blood pressure	13	7638	Mean Difference (IV, Random, 95% CI)	‐6.34 [‐9.03, ‐3.64]
2 Diastolic blood pressure	13	7628	Mean Difference (IV, Random, 95% CI)	‐3.33 [‐4.86, ‐1.79]
3 Systolic blood pressure: primary prevention trials	8	2463	Mean Difference (IV, Random, 95% CI)	‐8.67 [‐12.41, ‐4.94]
4 Systolic blood pressure: secondary prevention trial	5	5175	Mean Difference (IV, Random, 95% CI)	‐3.20 [‐6.98, 0.59]
5 Systolic blood pressure: comparator as usual care	5	4673	Mean Difference (IV, Random, 95% CI)	‐3.44 [‐7.61, 0.74]
6 Systolic blood pressure: placebo or inactive control	5	1245	Mean Difference (IV, Fixed, 95% CI)	‐10.77 [‐12.72, ‐8.81]
7 Systolic blood pressure: 3+ drugs only	9	5758	Mean Difference (IV, Random, 95% CI)	‐5.03 [‐8.13, ‐1.93]
8 Systolic blood pressure: 2 drugs	4	1870	Mean Difference (IV, Random, 95% CI)	‐9.56 [‐14.75, ‐4.38]