Comparison 4. Lipids.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total cholesterol	11	6565	Mean Difference (IV, Random, 95% CI)	‐0.61 [‐0.88, ‐0.35]
2 LDL cholesterol	12	7153	Mean Difference (IV, Random, 95% CI)	‐0.70 [‐0.98, ‐0.41]
3 Total cholesterol: primary prevention trials	7	2147	Mean Difference (IV, Random, 95% CI)	‐0.92 [‐1.18, ‐0.65]
4 Total cholesterol: secondary prevention trials	4	4417	Mean Difference (IV, Random, 95% CI)	‐0.16 [‐0.49, 0.17]
5 Total cholesterol: comparator as usual care	5	4620	Mean Difference (IV, Random, 95% CI)	‐0.16 [‐0.44, 0.12]
6 Total cholesterol: placebo or inactive control	4	1148	Mean Difference (IV, Random, 95% CI)	‐0.83 [‐0.99, ‐0.67]
7 Total cholesterol: 3+ drugs only	8	4792	Mean Difference (IV, Random, 95% CI)	‐0.48 [‐0.80, ‐0.16]
8 Total cholesterol: 2 drugs	3	1773	Mean Difference (IV, Random, 95% CI)	‐0.94 [‐1.50, ‐0.38]