CUSP 2009.

Methods	Individual‐level RCT
Participants	130 participants (66 intervention; 64 comparator) from the USA with coexisting, untreated hypertension (SBP = 140 mmHg‐169 mmHg or DBP = 90 mmHg‐105 mmHg) and dyslipidaemia (LDL‐C = 110 mg/dL‐160 mg/dL) but without a history of cardiovascular disease; age > 21 years
Interventions	Intervention: single pill amlodipine/atorvastatin (5 mg/20 mg) + therapeutic lifestyle changes Comparator: therapeutic lifestyle changes
Outcomes	Target for BP < 140/90 mm Hg and LDL‐C < 100 mg/dL (2.59 mmol ⁄L) at week 4 and week 8: the percentage of participants in whom the single LDL‐C goal was reached at weeks 4 and 8; mean changes from baseline in SBP and DBP at weeks 4 and 8; mean changes from baseline in LDL‐C at weeks 4 and 8; 10‐year Framingham risk of CHD at weeks 4 and 8
Notes	Comparator: inactive/usual care
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not specifically stated: "Patients were randomised in a double‐blind manner"
Allocation concealment (selection bias)	Unclear risk	Not specifically stated
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not specifically stated
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not specifically stated
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Unclear how data from participants lost to follow‐up were handled
Selective reporting (reporting bias)	Low risk	Primary outcomes reported (week 4 blood pressure and LDL targets)
Other bias	Low risk	No other sources of bias are identifiable