NCT01005290.

Methods	Randomised open‐label, cross‐over trial
Participants	Participants will be ≥ 18 years old. Previously untreated systolic pressure result of ≥ 120 < 160 mmHg and diastolic pressure result of ≥ 80 < 100 mmHg
Interventions	A once‐daily oral dose of the cardiovascular fixed‐dose combination pill (containing 100 mg acetylsalicylic acid, 40 mg simvastatin, and 5 mg ramipril) for 1 week followed by a once‐daily oral dose of the cardiovascular fixed‐dose combination pill (containing 100 mg acetylsalicylic acid, 40 mg simvastatin, and 10 mg ramipril) for 4 weeks Comparator: a once‐daily oral dose of 5 mg ramipril for 1 week followed by a once‐daily oral dose of 10 mg ramipril for 4 weeks
Outcomes	Primary outcomes Difference in the adjusted mean 24‐h systolic pressure results (using ABPM (ambulatory blood pressure monitoring)) between the basal and the final visit of each treatment period. (Time frame: days 7 and 36 of period 1 and days 49 and 85 of period 2.) (Designated as safety issue: no) Difference in the adjusted mean 24‐h systolic pressure results using ABPM in the PP population Secondary outcomes Difference in the adjusted mean 24‐h diastolic pressure results between the basal and the final visit of each treatment period. (Time frame: days 7 and 36 of period 1 and days 49 and 85 of period 2.) (Designated as safety issue: no) Difference in the adjusted mean 24‐h diastolic pressure results (using ABPM) between the basal and the final visit of each treatment period
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