NCT01362218.

Methods	Randomised open‐label, parallel assignment
Participants	Male or female participants aged ≥ 18 and < 75 years Previously untreated or not treated with fibrates during the last 6 weeks or with any other lipid‐lowering drug for the last 4 weeks LDL‐cholesterol ≥ 130 and ≤ 220 mg/dL Systolic blood pressure ≥ 120 and < 160 mmHg and diastolic blood pressure ≥ 70 and < 100 mmHg
Interventions	Drug: cardiovascular fixed‐dose combination pill (acetylsalicylic acid, simvastatin and ramipril) Comparator: simvastatin given together with the reference drugs ramipril and acetylsalicylic acid
Outcomes	Primary outcomes Difference in LDL‐cholesterol levels between the basal and the final visit of treatment period Secondary outcomes Difference in VLDL‐cholesterol levels between the basal and the final visit of treatment period Difference in HDL‐cholesterol levels between the basal and the final visit of treatment period Difference in total cholesterol levels between the basal and the final visit of treatment period Difference in triglyceride levels between the basal and the final visit of treatment period
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