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. 2016 Feb 22;2016(2):CD000521. doi: 10.1002/14651858.CD000521.pub3

1. Outcomes: Definitions and time points.

Outcome Study Definition Time point
Pneumonia Berggren 1987 "treated for" "during the postoperative period"
  Bigler 1985 Unspecified "postoperatively"
  Davis 1981 Chest X‐Ray in clinical suspicion Up to four weeks
  Heidari 2011 "diagnosed by the consultant specialist" "postoperative"
  McLaren 1978 "The clinical criteria adopted as indicating respiratory problems were productive cough, the presence of rhonchi or crepitations on auscultation or abnormalities on chest X‐ray." However the criteria adopted for the diagnosis of a pneumonia ("respiratory infection") are not clearly mentioned Up to four weeks
  Racle 1986 "clinical and radiological criteria" "in hospital"
  White 1980 Unspecified Within four weeks
Myocardial infarction Biboulet 2012 EKG and troponin measurement daily for three days, no definition provided Within one month
  Couderc 1977 Serial preprogrammed EKGs up to postoperative day 10 interpreted by
a blinded cardiologist. Q wave
In hospital
  Heidari 2011 "diagnosed by the consultant specialist" "postoperative"
  Juelsgaard 1998 World Health Organization criteria applied by a blinded investigator Within one month
Congestive cardiac failure Berggren 1987 "treated for" "during the postoperative period"
  Biboulet 2012 "acute heart failure" Within one month
  Bigler 1985 "cardiac decompensation" "postoperatively"
  Davis 1981 "life‐threatening complications" "congestive heart failure" Within four weeks
  Heidari 2011 "diagnosed by the consultant specialist" "postoperative"
  Racle 1986 "episode of congestive heart failure" In hospital
Cerebrovascular accident Berggren 1987 "stroke" All patients developed their stroke on postoperative day one
  Biboulet 2012 "stroke" Within one month
  Bigler 1985 "Neurological sequelae", apoplexy for the sole event reported "postoperatively"
  Davis 1981 "cerebrovascular accident" Within four weeks
  Heidari 2011 "cerebrovascular accident" "diagnosed by the consultant specialist" "postoperative"
  Racle 1986 "cerebrovascular accident" In hospital
Acute confusional state Berggren 1987 Diagnostic and Statistical Manual of Mental Disorders (DSM‐Ill) as criteria for acute confusional state Within seven days (the period 0‐8 hours after the surgery was excluded)
  Bigler 1985 "Mental confusion" "postoperatively"
  Casati 2003 Mini Mental State Examination test decreased 2 points from baseline Within seven days
  de Visme 2000 Mini Mental Status Examination lower than 5 Between the third and fifth postoperative day
  Heidari 2011 Cognitive dysfunction based on time, person, and place disorientation Up to postoperative day two
  Kamitani 2003 Delirium was judged by floor nurse, using the Inoue's confusion assessment method diagnosis algorithm Up to postoperative day four
  Racle 1986 Confusion with agitation In hospital
  White 1980 Unspecified Within four weeks
Renal failure (or acute kidney injury) Davis 1981 "acute renal failure" Within four weeks
  Racle 1986 Blood creatinine > 135 micromol/Liter In hospital
Deep vein thrombosis Brichant 1995 Systematic bilateral contrast venography Postoperative day ten
  Davis 1981 125‐iodine fibrinogen uptake test performed daily for seven days Within seven days
  Heidari 2011 "deep veins thrombosis" "diagnosed by the consultant specialist" "postoperative"
  Ibanez 1993 "thrombosis" Within seven days
  McKenzie 1984 Systematic venography Between postoperative day seven and ten
  White 1980 "deep vein thrombosis" Within four weeks
Pulmonary embolism Berggren 1987 "pulmonary embolism" "postoperatively"
  Bigler 1985 "pulmonary embolus" "postoperatively"
  Brichant 1995 Pulmonary venous angiogram or ventilation‐perfusion lung scanning on clinical suspicion Unclear
  Heidari 2011 "pulmonary emboli" "diagnosed by the consultant specialist" "postoperatively"
  Racle 1986 Clinical suspicion confirmed with angiography In hospital
Unsatisfactory surgical results Spreadbury 1980 Either an unstable fixation of the fracture by nail and plate or the dislocation of a prosthesis, which required bedrest on traction and prevented early mobilization In hospital
Operative hypotension Berggren 1987 Decrease > 30% from baseline for systolic arterial blood pressure Intraoperative
  Biffoli 1998 Decrease of 30% from baseline for arterial blood pressure Intraoperative
  Brown 1994 Requiring the administration of a sympathomimetic Intraoperative
  Casati 2003 Decrease in systolic arterial pressure 20% from baseline Intraoperative
  Couderc 1977 Decrease of 40 mmHG in systolic arterial blood pressure Intraoperative
  Davis 1987 Decrease in systolic arterial blood pressure > 20% from baseline Intraoperative
  Eyrolle 1998 Decrease in mean arterial blood pressure > 20% from baseline Intraoperative
  Juelsgaard 1998 Decrease in systolic arterial blood pressure > 33% from baseline Intraoperative
  Maurette 1988 Decrease in mean arterial blood pressure > 20% from baseline Intraoperative
  McLaren 1978 Decrease in systolic arterial blood pressure > 50% from baseline Intraoperative
  Messina 2013 Decrease in mean arterial blood pressure of 25% from baseline Intraoperative
  Racle 1986 Decrease in systolic arterial blood pressure of 20% from baseline Intraoperative
  Svarting 1986 Decrease in systolic arterial blood pressure > 30% from baseline Intraoperative
Urine retention Berggren 1987 "urinary retention" "postoperative"
  Cao 2008 "that required catheterization" In hospital

EKG: electrocardiogram