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. 2016 Feb 22;2016(2):CD000521. doi: 10.1002/14651858.CD000521.pub3

Brown 1994.

Methods RCT
Approved by the local Ethics Committee and signed written informed consent from each participant
Participants Orthopaedic hospital in Hong Kong
 20 ASA 2 or 3 patients with a proximal femoral fracture
 Mean age 77 years (range 66‐91)
 Male: 50%
 Number lost to follow‐up: not stated
Interventions Premedication with pethidine or temazepam
Treatment group: Spinal (subarachnoid) anaesthesia with 0.2 mg/kg hyperbaric bupivacaine (n = 10)
 Control group: General anaesthesia using thiopentone or propofol, isoflurane or enflurane atracurium and nitrous oxide/oxygen (n= 10)
Outcomes Operative hypotension (requiring administration of vasopressor)
Notes Length of follow‐up: 2 days (up to 44 hours)
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomized trial: use of random numbers table
Allocation concealment (selection bias) Unclear risk Not mentioned
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not mentioned
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Not mentioned
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No loss to follow‐up
Selective reporting (reporting bias) Low risk No failed neuraxial block mentioned
Other bias Low risk Groups well balanced