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. 2016 Feb 22;2016(2):CD000521. doi: 10.1002/14651858.CD000521.pub3

Couderc 1977.

Methods RCT
Participants Orthopaedic hospital in Paris, France
 100 patients with a proximal femoral fracture (nail and plate n = 56; hemiarthroplasty n = 44)
 Mean age 86 years. (Inclusion criterion: 80+ years; range not stated)
 Male: 14%
 Number lost to follow‐up: not stated
Operated within 24 hours after admission
Interventions Treatment group: Five to seven hundreds mL of fluid (LR or colloid). Neuraxial block (epidural anaesthesia) in lateral decubitus consisting of single shot or continuous infusion of 0.5% bupivacaine and adrenaline with or without lidocaine (n = 50)
 Control group: General anaesthesia with thiopentone, pancuronium or succinylcholine, dextromoramide or methoxyflurane, nitrous oxide/oxygen (n = 50)
Premedicated with hydroxyzine and atropine
Outcomes Mortality at 3 months (cumulative)
 Operative hypotension ( ≥ 40 mm HG; number of patients at induction of anaesthesia)
 Myocardial infarction (serial preprogrammed EKGs and enzymes)
Notes In French
Length of follow‐up: 3 months
 Complete data for fatal myocardial infarction, congestive heart failure and pulmonary embolism not provided
Early mobilization and anti‐vitamin K from day 3
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomized study: by 'drawing of lots'
Allocation concealment (selection bias) Unclear risk Not mentioned
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not mentioned
Blinding of outcome assessment (detection bias) 
 All outcomes High risk EKG interpreted by a blinded cardiologist. Not blinded for the other outcomes
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No loss to follow‐up
Selective reporting (reporting bias) Low risk No failed epidural reported
Other bias Low risk Groups well balanced