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. 2016 Feb 22;2016(2):CD000521. doi: 10.1002/14651858.CD000521.pub3

Davis 1987.

Methods RCT
Approved by the five Ethics Committee of the participating hospitals
Participants Orthopaedic hospitals in New Zealand ‐ multicentre study
 549 (538 analysed) participants with a proximal femoral fracture
 Mean age 79.5 years (range not stated)
 Male: 22%
 Number lost to follow‐up: 0, but 11 excluded
20% subcapital and 80% trochanteric fractures
Excluded if < 55 years of age, arthroplasty required, pathological fracture or contraindication to one anaesthetic technique
Interventions Treatment group: Spinal anaesthesia with sedation with diazepam. Hyper of isobaric tetracaine, nupercaine or bupivacaine for spinal (n= 259 analysed)
 Control group: General anaesthesia with pre‐oxygenation, IV induction with thiopentone, IPPV maintained with nitrous oxide/oxygen, non‐depolarizing neuromuscular blocker, fentanyl (n = 279 analysed)
Outcomes Mortality at 1 month (28 days)
 Operative hypotension requiring vasopressor
 Length of hospital stay
Notes There was 1 non fatal anaphylactoid reaction at induction of general anaesthesia
Length of follow‐up: 1 month
A longer duration of follow‐up was available for a fraction of the patients only and therefore was not reported to decrease the chances of selective reporting
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Randomized with stratification by sex and hospital
Allocation concealment (selection bias) Unclear risk Not mentioned
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not mentioned
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Not mentioned
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 11 excluded out of 549. Exclusion were made on pre‐defined criteria: age less than 55 years, multiple trauma, possible replacement or hemi‐arthroplasty or pathological fractures
Selective reporting (reporting bias) Low risk 30 failed spinal and 14 incomplete
Other bias Low risk Groups well balanced. Intention‐to‐treat