NCT02507505.

Trial name or title	Regional versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN): protocol for a pragmatic, international multicentre trial Ethics boards approval obtained
Methods	RCT, multicenter
Participants	1600 previously ambulatory participants aged 50 and older with a clinically or radiographically diagnosed intra‐ or extracapsular hip fracture and planned surgical treatment via hemiarthoplasty, total hip arthroplasty or appropriate fixation procedure Excluion criteria: planned concurrent surgery not amenable to spinal anaesthesia, contraindications to spinal anaesthesia, known susceptibility to malignant hyperthermia, periprosthetic fracture, prior participation to this trial, prisoner status or not being suitable for randomisation
Interventions	Intervention: spinal anaesthesia Control: general anaesthesia
Outcomes	Composite of death, new inability to walk 10 feet or across room at 60 days (blind assessor) Delirium (in‐hospital) Major inpatient hospital complication (in‐hospital) Mortality (in‐hospital, 60, 180 and 365 days) Acute postoperative pain (in‐hospital) Patient satisfaction (in‐hospital) Length of hospital stay (in‐hospital) Disease‐free survival (60, 180 and 365 days) Chronic pain (60, 180 and 365 days) Return to pre‐fracture residence (60, 180 and 365 days) Need for new assistive device for ambulation (60, 180 and 365 days) Cognitive impairment (60, 180 and 365 days)
Starting date	Recruitment began in February 2016 and will continue until the end of 2019
Contact information	Mark D Neuman
Notes	Expected results late 2020

BIS: bispectral index; CAM: Confusion Assessment Method ; mcg/kg: micrograms per kilogram of body weight; mL; millilitres; RCT: randomized controlled trial