| Methods | Randomized, double‐blind, placebo‐controlled 4 armed study |
| Participants | A total of 80 patients, M/F, ASA 1 and 2, age 18 to 65 years, having anxiety VAS score of 3 or more and planned for general anaesthesia for laparoscopic cholecystectomy |
| Interventions | 1) 0.5 mg alprazolam 2) 3 mg melatonin 3) combination 0.5 mg alprazolam and 3 mg melatonin 4) placebo 90 min before surgery |
| Outcomes | VAS anxiety score (baseline, 15 min, 30 min, 60 min after premedication), sedation score, orientation score, number of patients with intact memory, number of patients with loss of memory for being transferred to operating room |
| Notes |
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